Datacenter routing based on domain or URL

I wanted to understand how can I enable datacenter routing using domain or URL? We are planning to use F5 Networks / Akamai. Routing options I am looking at are for customer based routing and problematic zone is the call center context. Here are some options I have in mind 1.Domain based – www1.acme.com / www2.acme.com 2.URL based – www.acme.com/dc1/request , www.acme.com/dc2/request 3.Client Browser - update cookie on each navigation event I am looking for a robust approach with minimal/no change to server side or browser code.