Yep.
There's a couple of ways.
1. You could brute force change the host: header in the request every time via an iRule
2. You could test the host: header passed and
Checkout the [HTTP::header ...] commands in the iRules wiki for quick exampels of altering the host header.
or for more complex requirements, you can use a stream. That could be hard-coded (Via a stream profile), or implemented via an iRule (See the proxyPass iRule for an example - Requires a generic stream profile with no content added to the VS though).
Extra logic can be put in an iRule (If you don't use a hard-coded stream profile) to only perform the stream alterations for particular content. The advantage of a stream is the content would be altered too as well as the header.
H