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- HamishCirrocumulus
Absolutely.
The most common scenario is to have VS addresses one subnet and pool members 'behind' the big on another subnet.
You can configure it either way, though usually using the BigIP as the router between the two subnets (And inline between the client and the pool members) is the more common.
Bets practice? Debatable, but IMO inline is better. If you're doing single-armed then you'll either have to do SNAT, or policy routing in your network or on the hosts, and that can get messy.