Can LTM be used to configure Active and Passive Servers?

Key point is that

The OneConnect feature works with HTTP Keep-Alives to allow the BIG-IP system to minimize the number of server-side TCP connections by making existing connections available for reuse by other clients.

It needs HTTP Keep-Alives, my application is TCP only..

When a OneConnect profile is enabled for a TCP virtual server that does not have an HTTP profile applied, and a client sends multiple requests within a single connection, the BIG-IP system is able to process each request individually. The BIG-IP system sends the requests to different destination servers as determined by the load balancing method. Without a OneConnect profile enabled for the virtual server, the BIG-IP system performs load-balancing only once for each TCP connection.

Does that mean for new connection, not current connection?