BIG-IP VE - VMWare ESXi recommended settings

How well does Big-IP F5 work on VMWare Dynamic resource scheduler ?

we have successfully migrated a standalone physical to Virtual but soon after we had to revert as their were reach-ability issues with the virtual servers ? any guess on what could have caused the issue ?

currently the security settings on VMware for Promiscuous mode, mac address change and forged transits are set to reject. -- I suspect the issue might have been because of this setting.. but our device is only standalone. changing the vm settings is not easy without justification.