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Best practices for high traffic websites
Regarding OneConnect @Stephan Manthey also provided some good evidence that it reduces client-side connections too.
"OneConnect works bi-directional regarding KeepAlive (along to connection multiplexing, de-multiplexing and request switching). In case your servers doesn´t allow KeepAlive, the KeepAlive on clientside will still be maintained. OneConnect simply replaces the server´s 'Connection: close' by an 'X-cnection: close'. This helps to keep the clientside KeepAlive open. In a real world scenario it lowered the clientside TCP connection rate and TPS rate by 50+ percent."
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