APM Irule multiple access profile for one virtual server

You cannot, but you can usually work around this with VIP targeting. This is where you have one external VIP that sends traffic to internal VIPs using the virtual command. How you do this depends on how you have services divided on that external VIP. For example, if you have multiple host names all resolving to that one VIP, then the iRule might look like this:

when HTTP_REQUEST {
    switch [string tolower [HTTP::host]] {
        "app1.domain.com" { virtual app1_vs }
        "app2.domain.com" { virtual app2_vs }
        "app3.domain.com" { virtual app3_vs }
        "app4.domain.com" { virtual app4_vs }
    }
}

You can technically also do this with different URIs, but it's a lot trickier.