APM Client 7.2.1 vs F5 Access for Windows

the main difference is that the F5 Access client can be more easily managed by third party deployment tools and allows you to setup a VPN before login to Windows.

https://techdocs.f5.com/kb/en-us/products/big-ip_apm/manuals/related/apm-f5-access-windows-10-using-intune.html