Advantages and Disadvantages to trunk LTMs

You can dedicate a layer3 network to the front & back sides of the LTM, isolating it from all your traffic unless you specifically desire to send traffic that way. In a few of our environments we hang the LTM's in isolated layer3 networks off the core switches so no distro-distro hopping is necessary, but any direct client->server traffic that is necessary is not reliant on the LTM in any way.