Access Profile NTLM - Auth Configuration

Suspect the issue is due to the authentication header which IE send out when creating the access session.

Can you try the following the iRule?

when ACCESS_SESSION_STARTED { 
  if { [HTTP::header "Authorization"] ne "" } {
      set vContent {
                      
       }
      ACCESS::respond 200 content $vContent
      ACCESS::session remove
      unset vContent
  }
}