11.4 node/pool select according to domains list

Thanks, can I make it easier so if there is a match from the list then go to pool1 otherwise go to pool2, then I will just put the first half in the list without specifying a pool.

Certainly. Create the data group with the first set of domains, then modify the iRule accordingly:

when HTTP_REQUEST {
    if { [class match [string tolower [HTTP::host]] equals my_domain_dg] } {
        pool pool1
    } else {
        pool pool2        
    }
}

In this version, your data group entries don't have to have a corresponding pool or node value - just enter the domain name as the key and leave the value blank (we're not going to use it). Then create TWO pools: pool1 for domains that are in the data group, and pool2 for everything else.