iRule switch pool based on URI

BootsHasDrugs Would you be able to provide a bit more detail on exatly what you are attempting to do? The reason I ask is because the iRule seems sound with the exception of where you are defining the default pool and what mechanism you are using to define the default pool. I would configure the default pool as the pool associated to the virtual server and then define the pool using a slightly different command. Also, if you might consider creating a /32 OneConnect profile and assigning it to the virtual server so that it then performs a HOST and URI check per HTTP request rather than just on the initial HTTP request. I have also added some changes that use the following style guide.

https://community.f5.com/t5/technical-articles/irules-style-guide/ta-p/305921

The following should be how the iRule should look based on my comments.

when CLIENT_ACCEPTED priority 500 {

    set DEFAULT_POOL [LB::server pool]

}

when HTTP_REQUEST priority 500 {

	# Static variables
	set non_default_pool "sample-site.com-NON-DEFAULT"
    set hostlist [list sample-site.com]

		if { [lsearch $hostlist [string tolower [HTTP::host]]] ne -1 } {
          switch -glob [string tolower [HTTP::uri]] { 
			"/non-default-page/" -
			"/non-default-page/*" {
				pool ${non_default_pool}
			}
			default {
				pool ${DEFAULT_POOL}
			}
		}
	}

}