WannaCry Ransomware and MS17-010 Vulnerability
Published May 16, 2017
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SMB/CIFS cannot pass through a virtual server with an HTTP Profile on it, so you should be safe.
The caution against attaching the iRule to an HTTP virtual server simply reflects the fact that the Stream Profile filter it uses to efficiently scan the data stream for exploit sequences behaves differently when an HTTP Profile is present on the virtual server.