Configure the F5 BIG-IP as an Explicit Forward Web Proxy Using LTM

Since we move to the cloud we need a solution to nat applications to different ip's. As the clients are in the Azure env. i thought about setting up multiple of these proxy listeners. But as we set the nat on the wildcard VS i guess i can only nat to 1 ip address per proxy. Would it work to assign every proxy listener to a different routing domain?