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VIP not working if http profile added
There is something called delayed bind, that is probably causing the problem you have. Assuming, that the application does use HTTP.
F5 will wait until it receives HTTP data, so it can open a connection with the backend server. If F5 can't see the HTTP data, for example the server uses SSL/TLS and you don't a client SSL and server SSL profile, F5 will not be able to see the HTTP data inside of the encrypted packet.
If the problem is not SSL/TLS, please provide part of the problematic configuration and the version you have. Also, information about the backend server application.
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