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You can use an asynchronous task to create a UCS using REST

From the 13.0 REST API User Guide: https://devcentral.f5.com/d/icontrolr-rest-api-user-guide-version-1300-241

curl -X POST \
  https://192.168.25.42/mgmt/tm/task/sys/ucs \
  -H 'Content-Type: application/json' \
  -H 'X-F5-Auth-Token: ABCDEFG' \
  -d '    {
       "command": "save",
       "name": "myUcs"
    } '   

Using Python (3) You could use the following (code generated by Postman):

import http.client
conn = http.client.HTTPConnection("192,168,25,42")

payload = "{\"command\": \"save\",\"name\": \"myUcs\"}"
headers = {
    'X-F5-Auth-Token': "ABCDEFG",
    'Content-Type': "application/json",
    }

conn.request("POST", "mgmt,tm,task,sys,ucs", payload, headers)

res = conn.getresponse()
data = res.read()

print(data.decode("utf-8"))