TCP profile selection for small API call traffic

I was reading about TCP profile

tcp-lan-optimized

and

tcp-wan-optimized

traffic, currently we are using default

tcp

profile and we are not seeing any issue so far because our application is all API case so no human interaction or browsing there because our transaction is very small few api call but our traffic coming from all over the world over Internet.

1. Should we use

   wan

   and

   lan

   tcpd profile?
2. Should i disable Nagle on LAN side and enable it on WAN side?
3. or any other stuff i should keep in mind?