You can use the persist command (Click here) to specify how to persist the client, but you can't actually specify a custom persistence profile:

   
   when HTTP_REQUEST {   
      
       Persist based on the requested URI (case-insensitive)   
      switch -glob [string tolower [HTTP::uri]] {   
      
         "/twenty*" {   
             Persist the client for 20 minutes based on source IP with /32 mask   
            persist source_addr 255.255.255.255 1200   
         }   
         "/sixty*" {   
             Persist the client for 60 minutes based on source IP with /32 mask   
            persist source_addr 255.255.255.255 3600   
         }   
         default {   
             Take some default action?   
         }   
      }   
   }   
   

You should consider adding a OneConnect profile to the VIP when using a rule like this. (Click here) for details.

Aaron