Simplest ping is not working between cisco switch and F5

Connecting the internal & external VLAN cable coming from the core cisco switch to the laptop and configuring the laptop with internal self ip/gateway and external self ip/gateway the ping works and all the servers are responding to the ping indicating no issue towards uplink..

UWhile connecting it to the core switch using Layer-2 network with access ports on both sides, unable to move out of F5 LTM ahead of internal SELF IP which replying "Destination Host Un-reachable"..