Routing through cores

Has anyone setup their LTMS on a transit VLAN for the inside interface and then routed via a core layer (using OSPF in between the core and ltms) to the backend servers? The default route on each backend server would be the core layer and in turn, the core would have it's default route set to the load balancer. Is this not recommended or even possible due to the stripping of source and destination fields in the IP header by the core? I'm always seeing LTMs used with directly connected vlan interfaces and IPs on each backend subnet.

We've got other internal destination networks defined on the core that backend servers need to communicate with. Im not sure how else to allow them to route via the core to these destination nets without defining static routes to them, via the core on each server OR adding the routes to the ltms, which I would think would not be best practice (adds lots of extra net IO and cpu weight to the them).

Thanks! BJ