Rewrite host and URI, then redirect

Thanks Aaron. I did need to change the redirect again though to get it working. Something closer to my final is below. It looks like the cached URI was being passed in your example instead of what I thought I was updating with the string map. Changing that line a bit allowed me to change the redirect to reference the two variables instead.

 
  when HTTP_REQUEST {  
     switch [string tolower [HTTP::host]] {  
        "app.domain.com" {  
           set host "www.google.com"  
           set uri [string map -nocase {"/path_to_replace" "/new_path" "index.jsp" "index.asp"} [HTTP::uri]]  
           HTTP::redirect http://$host$uri  
        }  
     }  
  }