Redirect to different host and port based on URL

I want to only replace part of the URL i.e. sto, cph, bru, jnb with WOS will the above work for that?e.g.

[root@ve10:Active] config  b rule myrule list
rule myrule {
   when HTTP_REQUEST {
  switch [string tolower [HTTP::uri]] {
    /sto { set newhost "sto.domain";set newnode "200.200.200.101" }
    /cph { set newhost "cph.domain";set newnode "200.200.200.102" }
    /bru { set newhost "bru.domain";set newnode "200.200.200.103" }
    /jnb { set newhost "jnb.domain";set newnode "200.200.200.104" }
    default {
       do something
    }
  }
  HTTP::header replace Host $newhost
  HTTP::uri [string map {sto WOS cph WOS bru WOS jnb WOS} [HTTP::uri]]
  node $newnode 6500
}
}

[root@ve10:Active] config  ssldump -Aed -nni 0.0 port 80 or port 6500
New TCP connection 1: 172.28.20.17(38378) <-> 172.28.19.252(80)
1373275574.5080 (0.0007)  C>S
---------------------------------------------------------------
GET /sto HTTP/1.1
User-Agent: curl/7.15.5 (i686-redhat-linux-gnu) libcurl/7.15.5 OpenSSL/0.9.8b zlib/1.2.3 libidn/0.6.5
Accept: */*
Host: host.com

---------------------------------------------------------------

New TCP connection 2: 200.200.200.10(38378) <-> 200.200.200.101(6500)
1373275574.5103 (0.0010)  C>S
---------------------------------------------------------------
GET /WOS HTTP/1.1
User-Agent: curl/7.15.5 (i686-redhat-linux-gnu) libcurl/7.15.5 OpenSSL/0.9.8b zlib/1.2.3 libidn/0.6.5
Accept: */*
Host: sto.domain

---------------------------------------------------------------

you may use -glob switch option in case uri is not exact uri.

iRules 101 - 04 - Switch by Joe Pruitt

https://devcentral.f5.com/tech-tips/articles/irules-101-04-switch

The set newnode "200.200.200.101" should that be the IP of new hostyes

What is the virtual bar config for in the above example?it is standard virtual server with http profile. there is no pool because node command is used to send traffic to pool member.