Persistence source vs destination

Source IP persistence will make one client (=source) IP address "stick" to one member of your load balancing pool. There are lots of use cases for this scenario, so this is a quite common implementation.

Destination IP persistence will make all client requests (regardless of their source) that are destined to a certain DESTINATION IP address "stick" to one member of your load balancing pool. There are only few use cases for destination IP persistence. One such use case would be wild card virtuals that use a pool of firewalls as next hop.