Depending on details of your case, there's a lot of great documentation on our sites:
You could start with:
BIG-IP LTM 11.6.1 Documentation
https://support.f5.com/kb/en-us/products/big-ip_ltm/versions.11-6-1.html
Release Note: BIG-IP Virtual Edition 11.6.1
https://support.f5.com/kb/en-us/products/big-ip_ltm/releasenotes/product/relnote-ve-11-6-1.html
https://support.f5.com/kb/en-us/products/big-ip_ltm/versions.11-6-1.html
BIG-IP Virtual Edition Setup Guide for VMware ESXi
https://support.f5.com/kb/en-us/products/big-ip_ltm/manuals/product/bigip-ve-setup-vmware-esxi-11-6-0.html
Virtual Edition and Supported Hypervisors Matrix
https://support.f5.com/kb/en-us/products/big-ip_ltm/manuals/product/ve-supported-hypervisor-matrix.html
Updating a BIG-IP VE Virtual Machine
https://support.f5.com/kb/en-us/products/big-ip_ltm/manuals/product/bigip-ve-setup-vmware-esxi-11-6-0/3.htmlunique_90319829
Before your migration, you are advised to test your setup - as for the configuration of vNICs - if you're happy with your current connection's design, you could design them in the same way in the VE. As for the limiting yourself to only one vNIC will enforce you to utilize SNAT/AutoMap features. Some of licenses provides policers of traffic which will effectively limit your throughput.
--M .