Optimizing redirects to avoid TCL error "Multiple redirect/respond invocations"

You might have some conflicting logic between them.

An easy way to prevent this would be to use return statements after each one of your redirects that will cause the iRule to stop processing any other logic in that event and prevent any logic conflicts.

Something like this:

 
when HTTP_REQUEST {
  log local0. "Found [HTTP::host]"
if { [HTTP::path] equals "/" or [HTTP::path] equals "/vod" } {
HTTP::path "/vod/"
}
set rdr_target [class match -value [HTTP::uri] equals some_uri_redirects]
if { $rdr_target ne "" } {
HTTP::respond 301 Location $rdr_target
log local0. "Found match with value = $rdr_target"
return
}
if { [HTTP::path] starts_with "/watch" } {
HTTP::respond 301 Location "http://blabla/vod/page/default/home.do"
return
}
if { [HTTP::host] equals "blabla" } {
log local0. "Found [HTTP::host]"
set rdr_target [class match -value [HTTP::uri] equals someother_uri_redirects]
if { $rdr_target ne "" } {
HTTP::respond 301 Location $rdr_target
log local0. "Found match with value = $rdr_target for blabla"
return
}
else {
HTTP::respond 301 Location "http://blabla[HTTP::uri]"
}
}
}

If you are still getting this error after you have return statements look for logic conflicts in the other iRules that are applied to the Virtual Server.