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Issues with Exchange 2013 iApp on 11.4.1
Alex,
I just finished troubleshooting this same issue for over a month with F5 support. I didn't really want to accept the answer that you had to disable TLS 1.2 to get it working. I was running 11.3.1 with Exchange 2013 SP1 and while testing an upgrade to 11.4.1 I would lose Outlook Anywhere and Outlook Web Access connectivity to Exchange as soon as I failed over to the standby box running 11.4.1 HF8. When going to the OWA page, I would see Outlook Web Access displayed for a split second with the spinning wheel and then it would redirect to a page could not be found error.
I dug deeper, taking wireshark and ssl traces. I believe the issue is a mismatch between the ciphers that BIG IP 11.4.1 and Exchange 2013 servers use to negotiate. When looking over the supported ciphers in 11.5.1 I noticed there were some additional ones which weren't supported in 11.4.1. I went ahead and upgraded to 11.5.1 and as soon as I failed over everything was working as expected. If you would like my case I'd be happy to send it to you.
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