iRule to use specific HTTP profile

What type of customizations/differences do you have among the custom http profiles?

The only thing that I can tell is different is the urls that get encrypted cookies. Under our dev http profile, encrypt cookies field, we have 10 urs, like dev1, dev2, dev3, etc. We have the same for test and stage. I guess I am just trying to figure out is if there is a much simpler way to configure this rather than manually add a URL to the encrypt cookies field each time a new one is created.

You don't need to switch between HTTP profiles if you're just encrypting cookies. An iRule will do the job. Here's a variation of the HTTP cookie encryption article:

https://devcentral.f5.com/wiki/iRules.EncryptingCookies.ashx

when CLIENT_ACCEPTED {
    set cookielist [list "USERID" "METRICS"]
    set encryption_passphrase "abcd1234"
}
when HTTP_REQUEST {
    foreach x [HTTP::cookie names] {
        if { [lsearch $cookielist $x] ne "-1" } {
            set decrypted [HTTP::cookie decrypt $x $encryption_passphrase]
            if { $decrypted eq "" } {
                HTTP::cookie remove $x
            }
        }
    }
}
when HTTP_RESPONSE {    
    foreach x [HTTP::cookie names] {
        if { [lsearch $cookielist $x] ne "-1" } {
            HTTP::cookie encrypt $x $encryption_passphrase
        }
    }
}

Thanks for your help Kevin. I am still in the process of testing this.