iRule rewrite | URL hiding

when the 1st F5 sees the host "www.mysite.com" with a uri starting with "/help/site1/" and anything after it. It will pass the traffic to the 2nd F5 which has "news.bizsite.com:8080", the 2nd F5 will get the data/forms, etc to the pool on the 2nd F5 and return it to to the Internet user's browser. Correct for all?

yes

I created the iRule and associated it with the existing Virtual Server for "www.mysite.com". I'm not sure the iRule above works though. When I check the SSL dump, I didn't see the IP of "news.bizsite.com:8080".

you may try to debug irule.

iRules 101 - 09 - Debugging by Joe Pruitt