iRule Pool URI single node

You don't need to direct differently, because there is only ONE node available.

Everything will be handled on webserver level, means if the incoming URI starts with /app1 server will respond with content of app1 and if it's /app2 server will respond with content of app2.

So if the app-separating URI will already used to access the VS, nothing special needs to be configured on the BIG-IP.

Ciao Stefan :)