Irule giving error : Operation not supported. Multiple redirect/respond invocations not allowed

If I'm no mistaken you need to use "elseif" no to redirect twice ;).

when HTTP_REQUEST { 
if {([HTTP::uri] contains "credit-card-verification.page")||([HTTP::uri] contains "facebook.page")} {
    HTTP::redirect "https://[HTTP::host][HTTP::uri]"
} elseif {([string tolower [HTTP::uri]] starts_with "/ar/") and ([string tolower [HTTP::uri]] contains ".page") } {
    return
} elseif { (([HTTP::host] contains "zmiles.com") or ([HTTP::host] contains "www.zmiles.com")) } {
    HTTP::redirect "https://www.zways.com/en/Primary-Club.html"
} elseif { (([HTTP::host] equals "zways.ch") or ([HTTP::host] equals "www.zways.ch")) } {
    HTTP::respond 301 Location "http://www.zways.com/ch"
} elseif { (([HTTP::host] equals "zways.qa") or ([HTTP::host] equals "www.zways.qa")) } {
    HTTP::respond 301 Location "http://www.zways.com/qa"
} elseif {[string tolower [HTTP::host]] eq "zways.com"}{
    switch -glob [string tolower [HTTP::uri]] {
        "/en/*" -
        "/content/*" -
        "/apps/*" -
        "/etc/*" -
        "/zr/*" -
        "/libs/*" -
        "/bin/*" -
        "/en-*/*" -
        "/ar-*/" -
        "/ar/*" {
            HTTP::respond 301 Location "https://www.[HTTP::host][HTTP::uri]"
        }
    }

} elseif { ([string tolower [HTTP::host]] equals "www.zways.com") || ([string tolower [HTTP::host]] equals "originwww.zways.com") || ([string tolower [HTTP::host]] equals "zways.com") } {
    switch -glob [string tolower [HTTP::uri]] {
    "/en/*" -
    "/content/*" -
    "/apps/*" -
    "/etc/*"  -
    "/zr/*"   -
    "/libs/*" -
    "/bin/*"  -
    "/en-*/*" {
        HTTP::redirect "https://[HTTP::host][HTTP::uri]"
    }
    "/ar-*/*" -
    "/ar/*" {
        HTTP::respond 301 Location "https://[HTTP::host]/ar/homepage.html"
    }
    "/en-ae/*" -    
    "/en-sa/*" -    
    "/en-bh/*" -
    "/en-eg/*" -
    "/content/global/aa/*" { 
        HTTP::redirect "https://[HTTP::host]/en/homepage.html" 
    }
    "*-rain*" -
    "*-dam*" -
    "*-jed*" -
    "*-gas*" -
    "*-alex*" -
    "*-shar*" -
    "*-ras*" -
    "*-tai*" -
    "*-abh*" -
    "*-medi*" -
    "*-hof*" -
    "*-alex*" -
    "*-lux*" -
    "*-yan*" -
    "*-dub*" -
    "*-egt*" -
    "*-united-*" -
    "*-sauai*" -
    "*-car*" -
    "*-riya*" -
    "*-ababi*" -
    "*-dub*"   {
        set zrcom_uri [substr "[string tolower [HTTP::uri]]" 1 "/"]
        if { ($zrcom_uri contains "-") || ($zrcom_uri equals "en") || ($zrcom_uri equals "ar") } {
            log local0. "NEW: $zrcom_uri"
            HTTP::redirect "https://[HTTP::host]/$zrcom_uri/discover.html"
            }
            else {
                set old_zrcom_uri [substr "[string tolower [HTTP::uri]]" 1 5]
                log local0. "OLD: $old_zrcom_uri"
                HTTP::redirect "http://[HTTP::host]/$old_zrcom_uri/destinations.page"
            }
        }
    }
}

}