iRule for SSL certificate based on URL(path)

The answer is generally no from within an iRule. In order to see the URL for evaluation, you have to have already completed the SSL handshake. Can you elaborate on the Apache directive you're referring to? The Apache SSLRequire directive has the same limitation. You can enable/disable/switch SSL settings based on IP addresses (layer 4), and you can also force an SSL renegotiation (with client cert mutual authentication) based on some layer 7 URL path.