Implement F5 as forward proxy

I am trying to migrate Squid proxy to LTM to that all HTTP requests should be proxied by F5. The complexity increases with access control, we have 50 sets of servers accessing 50 sets of websites, squid handled them with ACL, not sure how F5 can handle such Implementation.

I do think AFM can solve it, but is there any limitations on ACL counts or address lists on AFM policies..??