Can you share some more details about the problem? Are there any error messages you can share? What modules are being used (LTM, APM, ASM)? Are there any iRules active on the virtual server that has problems?
We have LTM only used and there is an irule which only redirects based on the source IPs and hostnames to a particular pool member.
And now I could see post troubleshooting by doing a curl to below URLs
1) For working URL its giving HTTP 1.1 response. and its working. 2) For Non working URL direclty(bypassing f5) we can see the HTTP response code is 205 on HTTP/2. 3) For Non-Working URL via LB its giving us ssl error and we believe this is because we are getting response code on 205 via HTTP/2 and as we know HTTP/2 works only over TLS and we dont use serverssl.