How we can publish multiple applications on same VIP with same port & same irule?

Try this:

when HTTP_REQUEST {
SSL::disable
if { [string tolower [HTTP::host]] equals "abc.com" } {
    if { [string tolower[HTTP::uri]] contains "cvapweb" } {
            pool abc_9090 
    } 
    else {
            pool abc_8080
    }
}

elseif { [string tolower [HTTP::host]] equals "xyz.com" } {
    if { [string tolower [HTTP::uri]] contains "cvapweb" } {
            pool xyz_9090
    }
    else {
            pool xyz_9090
    }
}
}