how to use irule to customize use of persistence profile

it is going to be string comparison, so you do not need /32.

when CLIENT_ACCEPTED { 
  switch [IP::client_addr] { 
    "10.123.123.70" { persist source_addr } 
    "10.122.122.47" { persist none } 
    default { persist source_addr } 
  } 
}

what if I need to exclude complete subnet from persistence? say I don't want 10.124.124.0/24 use persistence.

how I can update it in iRule.

I believe you can do:

when CLIENT_ACCEPTED {
switch -glob [IP::client_addr] {
    "10.124.124.*" { persist none }
    default { persist source_addr }
}
}

I didn't get a chance to test, but this should work.

Thanks Brad. it works, however still I want to customized it.

how I can define perticular subnet like. 1.1.1.0/30 ?

You would just have to use the string rule, as IP::client_addr is a string value, so you could make the rules like

when CLIENT_ACCEPTED {
switch -glob [IP::client_addr] {
    "10.124.124.*" -
    "10.124.123.*" { persist none }
    default { persist source_addr }
}
}

I'm really not a pro at this, but this is the way that I do it.

I did a little digging and it looks like you can do the calculations like:

[IP::addr "10.0.0.0 mask 255.0.0.0" equals [IP::client_addr]]

https://devcentral.f5.com/wiki/iRules.ip__addr.ashx

You could also use a data group for that.