F5 configuration in front of SAP Messaging Server to let JCO calls (from Cloud) pass through and be processed at the SAP Back-end (on premise)

I have a project where there is a Java module being hosted in the Cloud, which needs to interact with the SAP back-end (in a different Datacenter). I would like to seek some Architectural guidance on putting F5s (a pair) in front of SAP Messaging Server, to let JCO calls (from the Cloud application) be passed through and processed at the SAP back-end (in the Datacenter).