f5 and Exchange 2010 Outlook 2010 password prompt

We had the same issue, I spent about 4 months on a support case with F5 before finally finding the fix. On the exchange http and https combined virtual server set the failback persistence profile to *appname*_source_address_persistence_profile. The latest downloadable iapp does this for you when you set it up.

 

 

Also under the Exchange source address persistence profile check both "match across services" and "match across virtual servers".

 

 

After doing the above steps and then deleted all existing persistence records for the virtual server the popups stopped.