Exactly how Destination Address Affinity persistence will work ?

Destination Address persistence persists based on the destination address. Any request to the same destination IP will persist to the same member.

Great example is directly from the Session Persistence section of the support site.

Think of an example where LTM is used to balance HTTP sessions for clients across a pool of caching proxies. By directing requests for the same resource (destination) to the same proxy, the efficiency of the cache increases. Destination address affinity ensures that requests to, for example, www.f5.com* always go to the same proxy.

• - A bit of an oversimplification...but the basic premise remains valid.