After working with F5 Support, SOL13180 worked for us. We are running 12.1.0 HF1.
Log into the F5 CLI and run the commands:
tmsh
modify /sys outbound-smtp mailhub [mail_server]:[port]
save /sys config
quit
Now test:
echo "ssmtp test mail" | mail -vs "Test email for SOL13180" [your_email_address]
Interestingly, this change resulted in our F5s sending non-deliverable emails to our SMTP server. We had to implement the workaround indicated in BUG ID 467589 of the 11.5.2 release notes.
Again, from the F5 CLI:
Remount the /usr partition as read-write:
mount -o remount -rw /usr
Edit the /usr/share/mysql/purge_mysql_logs.pl file and change this original line (line 27):
unless( $provisioned_am || $provisioned_asm || $provisioned_psm ) {
to this:
unless( $provisioned_am == 1 || $provisioned_asm == 1 || $provisioned_psm == 1 ) {
Save the file, and remount /usr as read-only:
mount -o remount -r /usr