Enable or disable chunking based on URI

I think the answer may be to set the Virtual Server to use HTTP 1.0 (in the HTTP profile) and trigger re-chunking on the application URL that requires re-chunking, using a modified iRule like:

when HTTP_REQUEST {
   if { [string tolower [HTTP::uri]] starts_with "/app-a" } {
      set app a
      HTTP::version "1.1"
   }
}
when HTTP_RESPONSE {
   if {$app == a} {
      HTTP::version "1.0"
      if {[HTTP::header exists "Transfer-Encoding"]} {
         HTTP::payload unchunk
         HTTP::header remove "Transfer-Encoding"
      }
   }
}