Does APM and SAML support WS-*. protocol for Office365

APM works with office 365 without an iRule - it leverages SAML 2.0 capabilities that do exist within Office 365. It mirrors the implementation and support that Microsoft has for leveraging Shibboleth SAML 2.0 IDP:

http://technet.microsoft.com/en-us/library/jj205456

Adding WS-Fed support to APM is something that will hopefully be added to the product in 2014.