client not support ssl to ssl supported server

firstly, configure the virtual server add a server ssl profile, the server ssl profile needs a cert and key

give your LTM configuration or screenshot(does LTM can ping pool members ip address?if LTM can ping, VS enable Automap,exclude network route problems ), list ltm virtual XXX. It is normal for us to test with bigip VE. At the same time, tcpdump is performed on the back-end server and in the LTM serverside direction to check out LTM whether send ClientHello packet in the serverside(when your back-end server performs https handshake whether want to force the ClientHello message to carry SNI fields?). Another point is that the URI in the normal format starts with "/",