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BIG-IP APM/LTM with Exchange 2010 and NTLM Authentication
Hello Jonathan, could you please confirm you are using the latest iAPP template for Exchange 2010/2013? Deployment guide with instructions to downloading the latest iAPP: http://www.f5.com/pdf/deployment-guides/microsoft-exchange-iapp-dg.pdf.
Once you have confirmed you are using the latest iAPP I would suggest reading through Appendix E. of the deployment guide linked above. There is some configuration required on Exchange and within the iAPP as well as on the big ip to get outlook anywhere (which is used by outlook clients) to work for NTLM auth to APM and Kerberos to the back end exchange servers.
Let me know if you have any further questions.
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