An error occured while fetching the URI

We have seen the same error for an SAP application with WAM configured. It's a bit confusing with those timeout and retries settings for destination host. We changed "Retries" from 2 to 0, which helped to avoid most of the duplicate requests to the backend system, and then extended both "timeout" and "R/W" to around 120 seconds, to minimized that URI error, maybe should extend timeout value more to totally get rid of the URI error. I'm not sure, waiting for application test feedback.