Adding a NIC to BIG-IP

Shouldn't be an issue configuring it later. I'd suggest however you at least check the new NIC hasn't caused any issues.

I've had issues a few times with vCloud where the MACs assigned to each NIC get messed up when you add or delete one. If this does happen you may need to do one of these (sometimes both) once you're sure things are setup right in vCloud;

[tmsh] stop sys services all
rm /var/db/mcpd*
reboot

If that doesn't work, this might;

touch /service/mcpd/forceload
shutdown –h now
Start from within vCloud