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In-Line or One-Arm LTM Placement
One more thing that nobody stated here , remember that F5's are not having full-state failover. From my 7 year experience I've seen situations and environments that this setup was a disaster since applications were not able to reconnect sessions after failover of F5 cluster. For me having inline is the last resort (i would run cluster in hybrid mode so we just use inline for particular vips when necassary).
Austin,
I am fully aware of connection mirroring but it's not a lightweight solution in terms of performance especially when you run hundreds of thousands of connections. It can be used in some exceptions but I never threat this as a standard configuration.
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