Unable to connect any resources after establishing VPN connection

Hello meowmeow  😺

Better see your network design as if you are using full vpn with no split tunnel (Network Access - Split Tunnel configuration) but full VPN (Article Detail) and maybe you are using Overview of BIG-IP Edge Client Always Connected mode (you mentioned that you can't connect even to the local network with the VPN on) then after the user traffic reaches the F5 device (by the way you can do tcpdump inside the tunnel Overview of packet tracing a BIG-IP APM Network Access tunnel with the tcpdump utility ) the F5 device should have appropriate routing in place to reach an external gateway for Internet and internal one for the Internal apps. Also check your Configuring Lease Pools as this ip addresses need to be routable in your environments.

I encourage you to take the F5 APM training if you have not done so or at least to read the F5 operations guides for tmos , apm and edge client as F5 is a complex system that has soo many options:

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