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SMTP outbound F5 Design
You're almost right! Since F5 is a default deny device, you must configure an object to accept and route this traffic flow. Usually, this is a Virtual Server. If F5 is the server's Gateway, you should account this VS to allow all the required connections. This means the VS should have wildcard destination. If a firewall is in place after the F5, I'm used to configuring this VIP in Forwarding (IP) mode and allow connections to "0.0.0.0/0 : any" and then filter traffic on the firewall. If you need NAT, you can configure it directly on the VS, or on the firewall if it's application-specific.
If you have routing domains in place, VS IP becomes "0.0.0.0/0%ID : any"
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