Persistence using source IP and source port

Hello Thompson,

Eventhough if we use NO SNAT since 2nd connection initiated by TMG, the internal loadbalancer only see the TMG server IP and not Internet client IPs.

The communication flow is like below.

Ist connection:(https) Internet (office365) --> External VIP --> Cisco ACE --> TMG server pool with 4 servers (external Interface).

2nd Connection:(https) 4 TMG servers (internal interface) --> Internal VIP -->F5 LTM --> CAS server pool with 10 servers.

If we use persistence only with source IP, only 4 CAS server will get most of connection (due to 4 TMG servers).

SSl offload & Session based cookie is not recommended solution for office365.

Is it possible to use a irule which take source IP and source port and do the persistence?

Thanks in advance.