Persistence through IRULE

First your

persist cookie

command is incomplete so to remove the need for the the Persistence profile on the virtual server (see the wiki iRule wiki: persist).

So should be the following:

persist cookie insert  

e.g.

persist cookie insert f5Cookie 0

Second I would put the

pool

selection command before the persist, not sure if you need to do this but always done it my self and more examples show this to be done, e.g.:

if {([HTTP::uri] contains "Communication") or ([HTTP::uri] contains "Builder") } {
    pool XYZ
    persist cookie insert f5Cookie 0
} elseif {([HTTP::uri] contains "PDFTemp") or ([HTTP::uri] contains "DOCTemp")} { 
    pool ABC
    persist none     
}

Finally if you want to make sure you are enforcing the pool and persistence selection on every HTTP request I would attach a OneConnect profile to the virtual server K7208: Overview of the OneConnect profile if you don't already have one.